While the MHRA has not yet approved its use, TOXBASE now lists the regime as a recognised treatment period. The same dose of N-acetylcysteine is administered in this regime but over a 12-hour ( not 21-hour) treatment period.

Clinical signs can also develop after days to weeks of therapeutic doses.This guideline reflects the local NHSGGC policy on acetylcysteine use in adult paracetamol overdoses and is based on the Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning (SNAP) regime.

Clinical signs can develop within 4-6 hours of ingesting a toxic dose.

The half-life of aspirin in dogs is about 8 hours.

Acute toxicity can result in hyperthermia due to the ability of aspirin to uncouple oxidative phosphorylation.

This leads to a respiratory alkalosis, followed by a metabolic acidosis Acid base imbalance.

Acute massive overdose can directly affect the respiratory center, leading to tachypnea.Salicylic acid irreversibly inhibits thromboxane activity, which inhibits platelet function.Renal blood flow can be affected, resulting in renal damage.Without the protection of prostaglandins and a direct effect of the drug, gastric ulceration can occur.Salicylic acid inhibits the cyclo-oxygenase system, which then inhibits the production of prostaglandins responsible for maintaining tissue homeostasis and modulating blood flow.Aspirin is metabolized by the liver to salicylic acid.Concurrent use with other non-steroidal anti-inflammatories or glucocorticoids also increases the risk of developing aspirin toxicity.Dehydrated animals are also more likely to develop renal damage.

Animals with underlying renal or hepatic disease are more likely to develop toxicity.

Clinical signs can develop within 4-6 hours after ingestion of a toxic dose.

Toxic signs typically develop at doses over 50 mg/kg/day.

In some animals, therapeutic doses can result in GI ulceration. The toxic dose of aspirin in dogs varies.

Toxicity often occurs due to accidental exposure or inappropriate administration by a well-meaning pet owner.

It is readily absorbed from the stomach and small intestine.

Since 1971, aspirin has been available for use in humans.

Acetylsalicylic acid has been used for its anti-inflammatory, antipyrexic, and analgesic properties for decades.

Antidote for asa overdose